Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer.
Marinela Couselo-SeijasCristina AlmenglóRosa M Agra-BermejoÁngel Luis FernandezEzequiel AlvarezJose R González-JuanateySonia EirasPublished in: European journal of clinical investigation (2020)
Epicardial fat cells expressed higher levels of ACE2 in comparison with subcutaneous fat cells, which is enhanced by diabetes and obesity presence in patients with cardiovascular disease. Both might be risk factors for SARS-CoV-2 infection.
Keyphrases
- cardiovascular disease
- type diabetes
- induced apoptosis
- cell cycle arrest
- metabolic syndrome
- insulin resistance
- adipose tissue
- weight loss
- cell death
- poor prognosis
- oxidative stress
- angiotensin ii
- coronary artery disease
- physical activity
- weight gain
- binding protein
- high fat diet induced
- skeletal muscle
- cell proliferation
- angiotensin converting enzyme
- body mass index
- clinical evaluation