Clinical Phenotype Classification of Atrial Fibrillation Patients Using Cluster Analysis and Associations with Trial-Adjudicated Outcomes.
Marco VitoloMarco ProiettiAlena ShantsilaGiuseppe BorianiGregory Yoke Hong LipPublished in: Biomedicines (2021)
Cluster analysis identified four different clinically relevant phenotypes of AF patients that had unique clinical characteristics and different outcomes. Cluster analysis highlights the high degree of heterogeneity in patients with AF, suggesting the need for a phenotype-driven approach to comorbidities, which could provide a more holistic approach to management aimed to improve patients' outcomes.
Keyphrases
- end stage renal disease
- atrial fibrillation
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- heart failure
- clinical trial
- randomized controlled trial
- deep learning
- coronary artery disease
- patient reported outcomes
- adipose tissue
- acute coronary syndrome
- open label
- left atrial
- percutaneous coronary intervention
- mitral valve
- catheter ablation
- direct oral anticoagulants
- double blind