M6A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression.

Pooja YadavPanneerdoss SubbarayaluDaisy M MedinaSaif NirzhorSantosh TimilsinaSubapriya RajamanickamVijay K EedunuriYogesh K Gupta Siyuan Zheng Nourhan AbdelfattahYufei HuangRatna K VadlamudiRobert HromasPaul S MeltzerPeter HoughtonYidong Chen Manjeet K Rao

Published in: Cancer research (2022)

RNA demethylase ALKBH5 upregulates USP22 and RNF40 to inhibit histone H2A ubiquitination and induces expression of key replication and DNA repair-associated genes, driving osteosarcoma progression.

Keyphrases

dna repair
dna damage response
dna damage
genome wide
dna methylation
poor prognosis
papillary thyroid
nucleic acid
squamous cell
squamous cell carcinoma
gene expression
young adults