A randomized, double-blind, dose-controlled study of the use of dexmedetomidine alone for procedural sedation of children and adolescents undergoing MRI scans.
Umar KhanGregory B HammerCassandra Duncan-AzadiYasuyuki SuzukiDeborah ChilesSunring ChimePhillip ChappellPublished in: Paediatric anaesthesia (2024)
Dexmedetomidine was well tolerated. The high dose was associated with meaningfully greater efficacy compared with lower doses. Based on these results, the recommended starting dose for procedural sedation in children ≥1month-<2years is loading dose 1.5 mcg/kg/maintenance infusion 1.5 mcg/kg/h; children ≥2-<17years is loading dose 2.0 mcg/kg/maintenance infusion 1.5 mcg/kg/h.
Keyphrases
- high dose
- low dose
- young adults
- magnetic resonance imaging
- cardiac surgery
- clinical trial
- double blind
- mechanical ventilation
- contrast enhanced
- randomized controlled trial
- intensive care unit
- magnetic resonance
- stem cell transplantation
- acute respiratory distress syndrome
- study protocol
- extracorporeal membrane oxygenation
- phase ii