Pediatric Soft Tissue Tumors With BCOR ITD Express EGFR but Not OLIG2.

Claudia M SalgadoAngelica ZinMarta GarridoIrina KletskayaRita DeVitoMiguel Reyes-MugicaGianni BisognoVittoria DonofrioRita Alaggio

Published in: Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society (2020)

EGFR is overexpressed in pediatric URCS/PMMTI with BCOR ITD and may be related to transcriptional upregulation of EGFR by BCOR ITD. OLIG2 negative staining differentiates URCS/PMMTI from CNS-HGNET. This finding may further support the possibility that these tumors have a different stem cell of origin.

Keyphrases

acute myeloid leukemia
small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
stem cells
clear cell
soft tissue
gene expression
transcription factor
blood brain barrier
poor prognosis
cell proliferation
signaling pathway
oxidative stress
young adults
long non coding rna
flow cytometry
cell therapy