PD-L1 Immunohistochemistry in Gastric Cancer: Comparison of Combined Positive Score and Tumor Area Positivity Across 28-8, 22C3, and SP263 Assays.

Samuel J Klempner Eric S Cowden Samuel L Cytryn Angelo Paolo Dei Tos Hiasto Kawakami Hideaki Shimada Laura H TangDaniel-Christoph WagnerYasushi Yatabe Alexander Savchenko Jennifer Salcius Dorhyun JohngJing ChenGiuliana MontenegroMarkus Möhler

Published in: JCO precision oncology (2024)

This study highlights analytical concordance in PD-L1 testing between three major PD-L1 assays when TAP and CPS are applied. Comparability of the technical assay performance was further supported by independent DIA. These observations support cross-application flexibility of the different PD-L1 assays and scoring algorithms to characterize PD-L1 expression in GC.

Keyphrases

high throughput
machine learning
deep learning
single cell
high resolution
liquid chromatography
gas chromatography
clinical evaluation