Tracking a TGF-β activator in vivo: sensitive PET imaging of αvβ8-integrin with the Ga-68-labeled cyclic RGD octapeptide trimer Ga-68-Triveoctin.

Neil Gerard QuigleyKatja SteigerFrauke RichterWilko WeichertSebastian HoberückJörg KotzerkeJohannes Notni

Published in: EJNMMI research (2020)

Ga-68-Triveoctin enables sensitive in-vivo imaging αvβ8-integrin expression in murine tumor xenografts. PET in a human subject confirmed a favorable biodistribution, underscoring the potential of Ga-68-Triveoctin for mapping of αvβ8-integrin expression in a clinical setting.

Keyphrases

pet ct
pet imaging
positron emission tomography
poor prognosis
high resolution
endothelial cells
cell migration
cell adhesion
binding protein
long non coding rna
computed tomography
induced pluripotent stem cells
immune response
mass spectrometry
signaling pathway
nuclear factor
fluorescence imaging