Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer.

Amrita M Nargund Chang Xu Amit Mandoli Atsushi Okabe Gao Bin ChenKie Kyon HuangTaotao ShengXiaosai Yao Jia Ming Nickolas Teo Raghav SundarYee Jiun KokYi Xiang SeeManjie XingZhimei LiChern Han YongAparna AnandZul Fazreen A ILai Fong PoonMichelle Shu Wen NgJavier Yu Peng KohWen Fong OoiSu Ting TayXuewen OngAngie Lay Keng TanHeike I GrabschMelissa J FullwoodTean Bin TehXuezhi Bi Atsushi KanedaShang LiPatrick Boon-Ooi Tan

Published in: Cancer research (2022)

DNA repair protein MSH2 binds and regulates cell adhesion genes by enabling enhancer-promoter interactions, and loss of MSH2 causes deficient cell adhesion and bromodomain and extraterminal motif inhibitor synthetic lethality in gastric cancer.

Keyphrases

cell adhesion
dna repair
dna damage
transcription factor
binding protein
genome wide
gene expression
dna methylation
dna damage response
oxidative stress