Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis.

Vincent HoLiping ChungAmandeep SinghVivienne LeaAskar AbubakarStephanie H LimWeng NgMark LeePaul de SouzaJoo-Shik ShinCheok Soon Lee

Published in: BMC cancer (2018)

Expression levels of MRN complex proteins significantly predict disease-free survival in rectal cancer patients, including those treated with neoadjuvant radiotherapy, and may have value in the management of these patients.

Keyphrases

rectal cancer
locally advanced
free survival
end stage renal disease
early stage
newly diagnosed
squamous cell carcinoma
radiation therapy
ejection fraction
poor prognosis
chronic kidney disease
lymph node
dna damage
cell proliferation
peritoneal dialysis
radiation induced
oxidative stress