Angiotensin-converting enzymes 1 and 2 in the feces: presence and catalytic activity in the rat 2,4,6-trinitrobenzene sulfonic acid-induced model of colitis.
Mariana Ferreira-DuarteLilian Caroline Gonçalves de OliveiraClara QuintasPatrícia Dias-PereiraTeresa SousaFernando MagroDulce Elena CasariniMargarida Duarte AraújoManuela MoratoPublished in: Journal of gastroenterology and hepatology (2024)
A 70 kDa ACE isoform only detected in the feces of TNBS-induced rats may have translational relevance. ACE N-domain seems to play a significant role in regulating colonic lesions. Further research using human samples is necessary to validate these findings.