Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.

Mustafa F AlkhouliJun HungMichaela SquireMiranda AndersonMonica CastroJeganathan R BabuLayla Al-NakkashTom L BroderickJeffrey H Plochocki

Published in: BMC complementary and alternative medicine (2019)

The 3xTg mouse model of AD is at elevated risk for limb bone fracture compared to wild type controls. Treatment with resveratrol, exercise, or both in combination improves fracture resistance and cross-sectional geometric indicators of bone strength.

Keyphrases

mouse model
wild type
cross sectional
high intensity
bone mineral density
hip fracture
physical activity
resistance training
bone loss
soft tissue
bone regeneration
cognitive decline
postmenopausal women
body composition
replacement therapy