Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.
Sanoj ChackoMamas A MamasMagdi El-OmarDavid SimonSohaib HaseebFarzin Fath-OrdoubadiBernard ClarkeLudwig NeysesWarwick B DunnPublished in: Metabolomics : Official journal of the Metabolomic Society (2021)
Using an untargeted metabolomics approach, the study identified important cardiac metabolic changes in peripheral and coronary sinus plasma, in a human model of controlled acute myocardial ischaemia. Distinct classes of metabolites were shown to be involved in the rapid cardiac response to ischemia and provide insights into diagnostic and interventional targets.
Keyphrases
- left ventricular
- endothelial cells
- liver failure
- mass spectrometry
- respiratory failure
- induced pluripotent stem cells
- pluripotent stem cells
- drug induced
- coronary artery
- aortic dissection
- heart failure
- ms ms
- aortic stenosis
- atrial fibrillation
- gas chromatography mass spectrometry
- acute respiratory distress syndrome
- high resolution