MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo.

Dominic HennMasood Abu-HalimaDominik WermkeFlorian FalknerBenjamin ThomasChristoph KöppleNicole LudwigMatthias SchulteMarc A BrockmannYoo-Jin KimJustin M SacksUlrich KneserAndreas KellerEckart MeeseVolker J Schmidt

Published in: Journal of translational medicine (2019)

Our data indicate that flow-stimulated angiogenesis is determined by an upregulation of cytokines, oxygenation associated genes and miRNA-dependent regulation of FOXC1, EPHA2 and SYNJ2BP.

Keyphrases

endothelial cells
vascular endothelial growth factor
wound healing
electronic health record
genome wide
cell proliferation
poor prognosis
transcription factor
signaling pathway
big data
blood flow
gene expression
machine learning