Curcumin piperidone derivatives induce caspase-dependent apoptosis and suppress miRNA-21 expression in LN-18 human glioblastoma cells.

Nur Syahirah Che RazaliKok Wai LamNor Fadilah RajabA Rahman A JamalNurul Farahana KamaludinKok Meng Chan

Published in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2024)

The FLDP-5 and FLDP-8 curcuminoid analogues downregulate the miRNA-21 expression and induce extrinsic and intrinsic apoptotic pathways in LN-18 cells.

Keyphrases

cell cycle arrest
induced apoptosis
cell death
endoplasmic reticulum stress
poor prognosis
oxidative stress
endothelial cells
signaling pathway
pi k akt
cell proliferation
anti inflammatory