Resilience, mental health, sleep, and smoking mediate pathways between lifetime stressors and Multiple Sclerosis severity.

Carri S PolickHala DarwishLeo Pestillo de OliveraAli WatsonJoao Ricardo Nickenig VissociPatrick S CalhounRobert Ploutz-SnyderCathleen M ConnellTiffany J BraleySarah A Stoddard

Published in: medRxiv : the preprint server for health sciences (2024)

This work provides foundational evidence to inform conceptualization of pathways by which stress could influence MS disease burden. Resilience may attenuate effects of stressors, while poor mental health, smoking, and sleep disturbances may exacerbate their impact. Parallel with usual care, these mediators could be targets for early multimodal therapies to improve disease course.

Keyphrases

mental health
multiple sclerosis
smoking cessation
climate change
healthcare
physical activity
sleep quality
mental illness
palliative care
mass spectrometry
social support
ms ms
white matter
risk factors
stress induced
health insurance