Butyrate supplementation to pregnant mice elicits cytoprotection against colonic injury in the offspring.
Maria E BarbianJoshua A OwensCrystal R NaudinPatricia W DenningRavi M PatelRheinallt M JonesPublished in: Pediatric research (2021)
Dietary butyrate supplementation to pregnant mice led to downregulation of colonic genes involved in inflammatory signaling and cholesterol synthesis, changes in the fecal microbiome composition of the offspring, and protection against experimentally induced colitis in the offspring. These data support the mounting evidence that the maternal diet during pregnancy has enduring effects on the offspring's long-term health and disease risk. Although further investigations are needed to identify the mechanism of butyrate's effects on fetal gut development, the current study substantiates the approach of dietary intervention during pregnancy to optimize the long-term gastrointestinal health of the offspring.
Keyphrases
- high fat diet
- healthcare
- public health
- mental health
- pregnant women
- randomized controlled trial
- weight loss
- adipose tissue
- oxidative stress
- type diabetes
- health information
- high fat diet induced
- physical activity
- cell proliferation
- machine learning
- risk assessment
- health promotion
- ulcerative colitis
- body mass index
- big data
- low density lipoprotein
- deep learning
- pregnancy outcomes