Clinical challenges of glioma and pregnancy: a systematic review.
Anouk van WestrhenenJ T SendersE MartinA C DiRisioM L D BroekmanPublished in: Journal of neuro-oncology (2018)
Findings from observational studies of adequate quality include (1) There is no known effect of pregnancy on survival in low-grade glioma patients; (2) Pregnancy can provoke clinical deterioration and tumor growth on MRI; (3) In stable women at term, there is no benefit of cesarean section over vaginal delivery, with respect to adverse events in mother or child. Unanswered questions include when pregnancy should be discouraged, what best monitoring schedule is for both mother and fetus, and if and how chemo- and radiation therapy can be safely administered during pregnancy. A multicenter individual patient level meta-analysis collecting granular information on clinical management and related outcomes is needed to provide scientific evidence for clinical decision-making in pregnant glioma patients.
Keyphrases
- low grade
- end stage renal disease
- radiation therapy
- pregnancy outcomes
- systematic review
- ejection fraction
- preterm birth
- chronic kidney disease
- newly diagnosed
- prognostic factors
- randomized controlled trial
- pregnant women
- healthcare
- preterm infants
- squamous cell carcinoma
- high grade
- drug delivery
- adipose tissue
- metabolic syndrome
- polycystic ovary syndrome
- patient reported
- contrast enhanced
- insulin resistance