Drug tolerability and reasons for discontinuation of seven biologics in elderly patients with rheumatoid arthritis -The ANSWER cohort study.

Kosuke EbinaMotomu HashimotoWataru YamamotoToru HiranoRyota HaraMasaki KatayamaAkira OnishiKoji NagaiYonsu SonHideki AmuroKeiichi YamamotoYuichi MaedaKoichi MurataSadao JinnoTohru TakeuchiMakoto HiraoAtsushi KumanogohHideki Yoshikawa

Published in: PloS one (2019)

ABT showed lowest discontinuation rate by lack of effectiveness and by toxic adverse events, which lead to highest overall retention rates (excluding non-toxic reasons and remission) among seven bDMARDs in adjusted model of elderly RA patients.

Keyphrases

end stage renal disease
ejection fraction
middle aged
newly diagnosed
randomized controlled trial
systematic review
community dwelling
disease activity
prognostic factors
emergency department
open label
clinical trial
drug induced
double blind
ulcerative colitis
placebo controlled