Safety and efficacy of colchicine in COVID-19 patients: A systematic review and meta-analysis of randomized control trials.

Farah YasminHala Najeeb Abdul MoeedWardah HassanMahima KhatriMuhammad Sohaib AsgharAhmed Kunwer NaveedWaqas UllahSalim R Surani

Published in: PloS one (2022)

Colchicine treatment decreased CRP levels and COVID-19 severity, with dimer levels, all-cause mortality and mechanical ventilation remaining seemingly unaffected. Thus, clinical trials need to be carried out that allow effective evaluation of colchicine in COVID-19 patients.

Keyphrases

mechanical ventilation
sars cov
clinical trial
acute respiratory distress syndrome
intensive care unit
coronavirus disease
double blind
open label
phase ii
phase iii
respiratory failure
placebo controlled
randomized controlled trial
study protocol
replacement therapy