Histopathological and molecular analysis of idiopathic pulmonary fibrosis lungs from patients treated with pirfenidone or nintedanib.
Yingwei ZhangKirk D JonesNatalia Achtar-ZadehGary GreenJasleen KukrejaBiyun XuPaul J WoltersPublished in: Histopathology (2018)
Pirfenidone and nintedanib do not modulate expression of senescence markers, levels of p-SMAD3 or the amount of fibrosis in IPF lungs. Treated patients have less histopathological evidence of acute lung injury at the time of lung transplantation.
Keyphrases
- idiopathic pulmonary fibrosis
- interstitial lung disease
- newly diagnosed
- end stage renal disease
- ejection fraction
- poor prognosis
- lipopolysaccharide induced
- peritoneal dialysis
- prognostic factors
- dna damage
- endothelial cells
- rheumatoid arthritis
- transforming growth factor
- extracorporeal membrane oxygenation
- lps induced
- inflammatory response
- systemic sclerosis