Does Methylphenidate Work in Children and Adolescents with Attention Deficit Hyperactivity Disorder?

Johanne Pereira RibeiroEmma Jasmine ArthurChristian GluudErik SimonsenOle Jakob Storebø

Published in: Pediatric reports (2021)

It appears that there is uncertain evidence on group-level to support the claim that methylphenidate is beneficial in treating children and adolescents with ADHD. Future randomised clinical trials and systematic reviews should include individual participant data, which would allow us to assess intervention effects across modifiers, like age, sex, ADHD subtypes, comorbidities, and dose.

Keyphrases

attention deficit hyperactivity disorder
clinical trial
autism spectrum disorder
systematic review
open label
randomized controlled trial
working memory
double blind
phase ii
study protocol
current status
electronic health record
big data
placebo controlled
meta analyses
phase iii
machine learning