Tumor-skin invasion is a reliable risk factor for poor prognosis in superficial soft tissue sarcomas.
Tadashi IwaiManabu HoshiNaoto OebisuNaoki TakadaYoshitaka BanHiroaki NakamuraPublished in: PloS one (2022)
Superficial soft tissue sarcomas have biologically been considered a separate category due to their better prognosis. In this study, the tumor-skin invasion was the only significant factor associated with a poor prognosis. Therefore, all superficial soft tissue sarcomas without tumor-skin invasion should be treated as early as possible.