Multidrug chemotherapy, whole-brain radiation and cytarabine therapy for primary central nervous system lymphoma in elderly patients with dose modification based on geriatric assessment: study protocol for a phase II, multicentre, non-randomised study.

Fumiyuki YamasakiHirotaka FudabaKenichiro AsanoTakashi SasayamaManabu NatsumedaTaichi ShimabukuroKotaro TaguchiShinichiro KoizumiNoriyuki NakayamaKentaro FujiiIkuno NishibuchiKazuhiko SugiyamaKenji YoshidaUshio YonezawaMomii YasutomoYukari KawasakiKiyohide KakutaKosuke KatayamaKazuhiro TanakaHiroaki NagashimaYoshihiro TsukamotoMakoto IdeguchiTakafumi NishizakiKazuhiko KurozumiTomohiro HosoyaTomoyuki AkitaAtsushi Kambe

Published in: BMJ open (2023)

jRCTs061180093.

Keyphrases

phase ii
clinical trial
open label
double blind
study protocol
placebo controlled
acute myeloid leukemia
phase iii
drug resistant
diffuse large b cell lymphoma
white matter
high dose
randomized controlled trial
middle aged
resting state
locally advanced
brain injury
multidrug resistant
blood brain barrier