ALPHA-METHYLTYROSINE (αMT) REDUCES THE ACUTE CARDIOVASCULAR AND BEHAVIORAL SEQUELAE IN A MURINE MODEL OF TRAUMATIC BRAIN INJURY (TBI).
Ryan WoodmanColeman MillerJeffrey StudentKalev FreemanDan PerlWarren LockettePublished in: The journal of trauma and acute care surgery (2023)
TBI acutely increases cardiovascular reactivity and induces behavioral deficits in an αMT-sensitive manner, most likely by inducing Nkcc1 gene transcription. αMT may prove salutary in the treatment of TBI by attenuating the enhanced expression of Nkcc1, minimizing blood brain barrier leakage, and diminishing central catecholamine and sympathetic output. We also found an unreported relationship between Kcc2 and the chloride/bicarbonate exchanger which should be considered in the design of trials planned to manipulate central intraneuronal chloride concentrations following acute brain injury.
Keyphrases
- traumatic brain injury
- brain injury
- blood brain barrier
- liver failure
- cerebral ischemia
- subarachnoid hemorrhage
- respiratory failure
- severe traumatic brain injury
- drug induced
- aortic dissection
- poor prognosis
- genome wide
- gene expression
- dna methylation
- combination therapy
- replacement therapy
- acute respiratory distress syndrome
- genome wide identification