MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2.

Weidong JiangPeiqi ZhuTao ZhangFengchun LiaoYangyang YuYan LiuHuijuan ShenZhenchen ZhaoXuanping HuangNuo Zhou

Published in: Stem cell research & therapy (2021)

MiR-205 is a significant regulator of the MDO process, and inhibiting this miRNA can accelerate MDO-related mineralization. Overall, these results offer new insights into the mechanistic basis for this procedure, highlighting potential targets for therapeutic clinical intervention.

Keyphrases

transcription factor
cell proliferation
randomized controlled trial
long non coding rna
long noncoding rna
endothelial cells
minimally invasive
human health
cell fate