Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.
Xiaohui YanJian-Jun ChenAjeeth AdhikariDong YangIvana CrnovcicNan WangChin-Yuan ChangChristoph RaderBen ShenPublished in: Organic letters (2017)
A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome databases and prioritizing the hits by an enediyne genome neighborhood network analysis for discovery. YPM A is potent against a broad spectrum of human cancer cell lines. The discovery of 1 provides new opportunities for the functionalization of enediynes to develop new conjugation chemistries for antibody-drug conjugates.
Keyphrases
- network analysis
- genome wide
- small molecule
- endothelial cells
- high throughput
- papillary thyroid
- healthcare
- dna methylation
- copy number
- physical activity
- emergency department
- induced pluripotent stem cells
- squamous cell
- cancer therapy
- machine learning
- squamous cell carcinoma
- gene expression
- young adults
- transcription factor