Ben Shen

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 82

Top Topics

Crystal Structure

Toxoplasma Gondii

Staphylococcus Aureus

Top Venues

bioRxiv : the preprint server for biology

Organic letters

Journal of medicinal chemistry

Journal of natural products

This page only lists publications with an associated author ORCID identifier.

Publications

Lucas L Fluegel, Ming-Rong Deng, Ping Su, Edward Kalkreuter, Dong Yang, Jeffrey D Rudolf, Liao-Bin Dong, Ben Shen
Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. Journal of industrial microbiology & biotechnology 51 (2024)
Chun Gui, Edward Kalkreuter, Lukas Lauterbach, Dong Yang, Ben Shen
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate. Nature chemical biology (2024)
Lucas L Fluegel, Ming-Rong Deng, Ping Su, Edward Kalkreuter, Dong Yang, Jeffrey D Rudolf, Liao-Bin Dong, Ben Shen
Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. Journal of industrial microbiology & biotechnology (2024)
Chun Gui, Edward Kalkreuter, Lukas Lauterbach, Dong Yang, Ben Shen
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate. Nature chemical biology 20 (9) (2024)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Chantal D Bader, Christiana N Teijaro, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Lukas Lauterbach, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Layla Schuster, Tyler M Cowan, Michael J Smanski, Marc G Chevrette, Luiz P S de Carvalho, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2024)
Lucas L Fluegel, Ming-Rong Deng, Ping Su, Edward Kalkreuter, Dong Yang, Jeffrey D Rudolf, Liao-Bin Dong, Ben Shen
Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. Journal of industrial microbiology & biotechnology 51 (2024)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Layla Schuster, Tyler M Cowan, Michael J Smanski, Marc G Chevrette, Luiz P S de Carvalho, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2024)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Chantal D Bader, Christiana N Teijaro, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Lukas Lauterbach, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Layla Schuster, Tyler M Cowan, Michael J Smanski, Marc G Chevrette, Luiz P S de Carvalho, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2024)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Chantal D Bader, Christiana N Teijaro, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Lukas Lauterbach, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Layla Schuster, Tyler M Cowan, Michael J Smanski, Marc G Chevrette, Luiz P S de Carvalho, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2024)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Chantal D Bader, Christiana N Teijaro, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Lukas Lauterbach, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Layla Schuster, Tyler M Cowan, Michael J Smanski, Marc G Chevrette, Luiz P S de Carvalho, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2024)
Lucas L Fluegel, Ming-Rong Deng, Ping Su, Edward Kalkreuter, Dong Yang, Jeffrey D Rudolf, Liao-Bin Dong, Ben Shen
Development of platensimycin, platencin, and platensilin overproducers by biosynthetic pathway engineering and fermentation medium optimization. Journal of industrial microbiology & biotechnology 51 (2024)
Elnaz Jalali, Fengbin Wang, Brooke R Overbay, Mitchell D Miller, Khaled A Shaaban, Larissa V Ponomareva, Qing Ye, Hoda Saghaeiannejad-Esfahani, Minakshi Bhardwaj, Andrew D Steele, Christiana N Teijaro, Ben Shen, Steven G Van Lanen, Qing-Bai She, S Randal Voss, George N Phillips, Jon S Thorson
Biochemical and Structural Studies of the Carminomycin 4- O -Methyltransferase DnrK. Journal of natural products (2024)
Elnaz Jalali, Fengbin Wang, Brooke R Overbay, Mitchell D Miller, Khaled A Shaaban, Larissa V Ponomareva, Qing Ye, Hoda Saghaeiannejad-Esfahani, Minakshi Bhardwaj, Andrew D Steele, Christiana N Teijaro, Ben Shen, Steven G Van Lanen, Qing-Bai She, S Randal Voss, George N Phillips, Jon S Thorson
Biochemical and Structural Studies of the Carminomycin 4- O -Methyltransferase DnrK. Journal of natural products 87 (4) (2024)
Andrew D Steele, Hui Jiang, Guohui Pan, Si-Kyu Lim, Edward Kalkreuter, Thomas Kwong, Jianhua Ju, Scott Rajski, Ben Shen
Discrete Acyltransferases and Thioesterases in Iso-Migrastatin and Lactimidomycin Biosynthesis. Biochemistry (2024)
Chun Gui, Edward Kalkreuter, Lukas Lauterbach, Dong Yang, Ben Shen
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate. Nature chemical biology (2024)
Elnaz Jalali, Fengbin Wang, Brooke R Overbay, Mitchell D Miller, Khaled A Shaaban, Larissa V Ponomareva, Qing Ye, Hoda Saghaeiannejad-Esfahani, Minakshi Bhardwaj, Andrew D Steele, Christiana N Teijaro, Ben Shen, Steven G Van Lanen, Qing-Bai She, S Randal Voss, George N Phillips, Jon S Thorson
Biochemical and Structural Studies of the Carminomycin 4- O -Methyltransferase DnrK. Journal of natural products 87 (4) (2024)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Layla Schuster, Tyler M Cowan, Michael J Smanski, Marc G Chevrette, Luiz P S de Carvalho, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2024)
Chun Gui, Edward Kalkreuter, Lukas Lauterbach, Dong Yang, Ben Shen
Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate. Nature chemical biology 20 (9) (2024)
Andrew D Steele, Alexander F Kiefer, Dobeen Hwang, Dong Yang, Christiana N Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. Journal of medicinal chemistry 66 (2) (2023)
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Cheng-Jian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. Organic letters 25 (6) (2023)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2023)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2023)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2023)
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Cheng-Jian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. Organic letters (2023)
Andrew D Steele, Alexander F Kiefer, Dobeen Hwang, Dong Yang, Christiana N Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. Journal of medicinal chemistry 66 (2) (2023)
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Cheng-Jian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. Organic letters 25 (6) (2023)
Andrew D Steele, Alexander F Kiefer, Dobeen Hwang, Dong Yang, Christiana N Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. Journal of medicinal chemistry 66 (2) (2023)
Andrew D Steele, Alexander F Kiefer, Dobeen Hwang, Dong Yang, Christiana N Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. Journal of medicinal chemistry 66 (2) (2023)
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Cheng-Jian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. Organic letters 25 (6) (2023)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2023)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2023)
Edward Kalkreuter, Satria A Kautsar, Dong Yang, Christiana N Teijaro, Chantal D Bader, Lucas L Fluegel, Christina M Davis, Johnathon R Simpson, Andrew D Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J Cepeda, Wei Yan, Bo-Yi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, Ben Shen
The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity. bioRxiv : the preprint server for biology (2023)
Chun Gui, Edward Kalkreuter, Yu-Chen Liu, Gengnan Li, Andrew D Steele, Dong Yang, Changsoo Chang, Ben Shen
Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nature chemical biology (2023)
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Cheng-Jian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. Organic letters 25 (6) (2023)
Andrew D Steele, Alexander F Kiefer, Dobeen Hwang, Dong Yang, Christiana N Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. Journal of medicinal chemistry (2023)
Andrew D Steele, Alexander F Kiefer, Dobeen Hwang, Dong Yang, Christiana N Teijaro, Ajeeth Adhikari, Christoph Rader, Ben Shen
Application of a Biocatalytic Strategy for the Preparation of Tiancimycin-Based Antibody-Drug Conjugates Revealing Key Insights into Structure-Activity Relationships. Journal of medicinal chemistry 66 (2) (2023)
Mingming Cao, Dong Yang, Ajeeth Adhikari, Fei Ye, Cheng-Jian Zheng, Wei Yan, Song Meng, Ping Su, Ben Shen
Neogrisemycin, a Trisulfide-Bridged Angucycline, Produced upon Expressing the Thioangucycline Biosynthetic Gene Cluster in Streptomyces albus J1074. Organic letters 25 (6) (2023)
Dong Yang, Fei Ye, Christiana N Teijaro, Dobeen Hwang, Thibault Annaval, Ajeeth Adhikari, Gengnan Li, Xiaohui Yan, Chun Gui, Christoph Rader, Ben Shen
Functional Characterization of Cytochrome P450 Hydroxylase YpmL in Yangpumicin A Biosynthesis and Its Application for Anthraquinone-Fused Enediyne Structural Diversification. Organic letters 24 (5) (2022)
Chun Gui, Edward Kalkreuter, Yu-Chen Liu, Ajeeth Adhikari, Christiana N Teijaro, Dong Yang, Changsoo Chang, Ben Shen
Intramolecular C-C Bond Formation Links Anthraquinone and Enediyne Scaffolds in Tiancimycin Biosynthesis. Journal of the American Chemical Society 144 (44) (2022)
Fei Ye, Hafeez S Haniff, Blessy M Suresh, Dong Yang, Peiyuan Zhang, Gogce Crynen, Christiana N Teijaro, Wei Yan, Daniel Abegg, Alexander Adibekian, Ben Shen, Matthew D Disney
Rational Approach to Identify RNA Targets of Natural Products Enables Identification of Nocathiacin as an Inhibitor of an Oncogenic RNA. ACS chemical biology 17 (2) (2022)
Hindra Hindra, Dong Yang, Jun Luo, Tingting Huang, Xiaohui Yan, Ajeeth Adhikari, Christiana N Teijaro, Huiming Ge, Ben Shen
Submerged fermentation of Streptomyces uncialis providing a biotechnology platform for uncialamycin biosynthesis, engineering, and production. Journal of industrial microbiology & biotechnology 48 (3-4) (2021)
Ming-Ming Cao, Cheng-Jian Zheng, Dong Yang, Edward Kalkreuter, Ajeeth Adhikari, Yu-Chen Liu, Mostafa E Rateb, Ben Shen
Cryptic Sulfur Incorporation in Thioangucycline Biosynthesis. Angewandte Chemie (International ed. in English) 60 (13) (2021)
Edward Kalkreuter, Ben Shen
MIO-containing aminomutases for α- to β-amino acids. Trends in chemistry 4 (1) (2021)
Jun Luo, Dong Yang, null Hindra, Ajeeth Adhikari, Liao-Bin Dong, Fei Ye, Xiaohui Yan, Christoph Rader, Ben Shen
Discovery of ammosesters by mining the Streptomyces uncialis DCA2648 genome revealing new insight into ammosamide biosynthesis. Journal of industrial microbiology & biotechnology 48 (3-4) (2021)
Thibault Annaval, Christiana N Teijaro, Ajeeth Adhikari, Xiaohui Yan, Jian-Jun Chen, Ivana Crnovcic, Dong Yang, Ben Shen
Cytochrome P450 Hydroxylase TnmL Catalyzing Sequential Hydroxylation with an Additional Proofreading Activity in Tiancimycin Biosynthesis. ACS chemical biology 16 (7) (2021)
Song Meng, Andrew D Steele, Wei Yan, Guohui Pan, Edward Kalkreuter, Yu-Chen Liu, Zhengren Xu, Ben Shen
Thiocysteine lyases as polyketide synthase domains installing hydropersulfide into natural products and a hydropersulfide methyltransferase. Nature communications 12 (1) (2021)
Wenqing Zhou, Haoyu Liang, Xiangjing Qin, Danfeng Cao, Xiangcheng Zhu, Jianhua Ju, Ben Shen, Yanwen Duan, Yong Huang
The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster. Journal of natural products 83 (2) (2020)
Xingyun Liu, Zhe Wang, Xueqiong Feng, Enhe Bai, Yi Xiong, Xiangcheng Zhu, Ben Shen, Yanwen Duan, Yong Huang
Platensimycin-Encapsulated Poly(lactic-co-glycolic acid) and Poly(amidoamine) Dendrimers Nanoparticles with Enhanced Anti-Staphylococcal Activity in Vivo. Bioconjugate chemistry 31 (5) (2020)
Cheng-Jian Zheng, Edward Kalkreuter, Bo-Yi Fan, Yu-Chen Liu, Liao-Bin Dong, Ben Shen
PtmC Catalyzes the Final Step of Thioplatensimycin, Thioplatencin, and Thioplatensilin Biosynthesis and Expands the Scope of Arylamine N-Acetyltransferases. ACS chemical biology 16 (1) (2020)
Ajeeth Adhikari, Christiana N Teijaro, Xiaohui Yan, Chin-Yuan Chang, Chun Gui, Yu-Chen Liu, Ivana Crnovcic, Dong Yang, Thibault Annaval, Christoph Rader, Ben Shen
Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. Journal of medicinal chemistry 63 (15) (2020)
Zhe Wang, Xingyun Liu, Ying Peng, Meng Su, Saibin Zhu, Jian Pan, Ben Shen, Yanwen Duan, Yong Huang
Platensimycin-Encapsulated Liposomes or Micelles as Biosafe Nanoantibiotics Exhibited Strong Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus Infection in Mice. Molecular pharmaceutics 17 (7) (2020)
Jeremy R Lohman, Ben Shen
The LnmK Bifunctional Acyltransferase/Decarboxylase Specifying (2R)-Methylmalonyl-CoA and Employing Substrate-Assisted Catalysis for Polyketide Biosynthesis. Biochemistry 59 (43) (2020)
Xiao Zhang, Emma King-Smith, Liao-Bin Dong, Li-Cheng Yang, Jeffrey D Rudolf, Ben Shen, Hans Renata
Divergent synthesis of complex diterpenes through a hybrid oxidative approach. Science (New York, N.Y.) 369 (6505) (2020)
Meng Su, Lin Qiu, Youchao Deng, Claudia H Ruiz, Jeffrey D Rudolf, Liao-Bin Dong, Xueqiong Feng, Michael D Cameron, Ben Shen, Yanwen Duan, Yong Huang
Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models. Molecular pharmaceutics 16 (7) (2019)
Liao-Bin Dong, Yu-Chen Liu, Alexis J Cepeda, Edward Kalkreuter, Ming-Rong Deng, Jeffrey D Rudolf, Changsoo Chang, Andrzej Joachimiak, George N Phillips, Ben Shen
Characterization and Crystal Structure of a Nonheme Diiron Monooxygenase Involved in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society 141 (31) (2019)
Zhengren Xu, Shi-Ming Fang, Malina A Bakowski, Mostafa E Rateb, Dong Yang, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Mitchell V Hull, Case W McNamara, Ben Shen
Discovery of Kirromycins with Anti- Wolbachia Activity from Streptomyces sp. CB00686. ACS chemical biology 14 (6) (2019)
Liao-Bin Dong, Xiao Zhang, Jeffrey D Rudolf, Ming-Rong Deng, Edward Kalkreuter, Alexis J Cepeda, Hans Renata, Ben Shen
Cryptic and Stereospecific Hydroxylation, Oxidation, and Reduction in Platensimycin and Platencin Biosynthesis. Journal of the American Chemical Society 141 (9) (2019)
Youchao Deng, Xiang Weng, Yuling Li, Meng Su, Zhongqing Wen, Xinxin Ji, Nan Ren, Ben Shen, Yanwen Duan, Yong Huang
Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo. Journal of medicinal chemistry 62 (14) (2019)
Zilong Wang, Zhongqing Wen, Ling Liu, Xiangcheng Zhu, Ben Shen, Xiaohui Yan, Yanwen Duan, Yong Huang
Yangpumicins F and G, Enediyne Congeners from Micromonospora yangpuensis DSM 45577. Journal of natural products 82 (9) (2019)
Youchao Deng, Meng Su, Dingding Kang, Xingyun Liu, Zhongqing Wen, Yuling Li, Lin Qiu, Ben Shen, Yanwen Duan, Yong Huang
Semisynthesis of Platensimycin Derivatives with Antibiotic Activities in Mice via Suzuki-Miyaura Cross-Coupling Reactions. Journal of medicinal chemistry 61 (24) (2018)
Christiana N Teijaro, Ajeeth Adhikari, Ben Shen
Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts. Journal of industrial microbiology & biotechnology 46 (3-4) (2018)
Xiaohui Yan, null Hindra, Hui Ming Ge, Dong Yang, Tingting Huang, Ivana Crnovcic, Chin-Yuan Chang, Shi-Ming Fang, Thibault Annaval, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Ben Shen
Discovery of Alternative Producers of the Enediyne Antitumor Antibiotic C-1027 with High Titers. Journal of natural products 81 (3) (2018)
Youchao Deng, Dingding Kang, Jie Shi, Wenqing Zhou, Aijun Sun, Jianhua Ju, Xiangcheng Zhu, Ben Shen, Yanwen Duan, Yong Huang
The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. MedChemComm 9 (5) (2018)
Zhengren Xu, Guohui Pan, Hao Zhou, Ben Shen
Discovery and Characterization of 1-Aminocyclopropane-1-carboxylic Acid Synthase of Bacterial Origin. Journal of the American Chemical Society 140 (49) (2018)
James B McAlpine, Shao-Nong Chen, Andrei G Kutateladze, John B MacMillan, Giovanni Appendino, Andersson Barison, Mehdi A Beniddir, Maique Weber Biavatti, Stefan Bluml, Asmaa Boufridi, Mark S Butler, Robert J Capon, Young Hae Choi, David Coppage, Phillip Crews, Michael T Crimmins, Marie Csete, Pradeep Dewapriya, Joseph M Egan, Mary J Garson, Grégory Genta-Jouve, William H Gerwick, Harald Gross, Mary Kay Harper, Precilia Hermanto, James M Hook, Luke Hunter, Damien Jeannerat, Nai-Yun Ji, Tyler A Johnson, David G I Kingston, Hiroyuki Koshino, Hsiau-Wei Lee, Guy Lewin, Jie Li, Roger G Linington, Miaomiao Liu, Kerry L McPhail, Tadeusz F Molinski, Bradley S Moore, Joo-Won Nam, Ram P Neupane, Matthias Niemitz, Jean-Marc Nuzillard, Nicholas H Oberliels, Fernanda Maria Marins Ocampos, Guohui Pan, Ronald J Quinn, D Sai Reddy, Jean-Hugues Renault, José Rivera-Chávez, Wolfgang Robien, Carla M Saunders, Thomas Jürgen Schmidt, Christoph Seger, Ben Shen, Christoph Steinbeck, Hermann Stuppner, Sonja Sturm, Taglialatela-Scafati Orazio, Dean Joseph Tantillo, Robert Verporte, Bin-Gui Wang, Craig M Williams, Philip G Williams, Julien Wist, Jian-Min Yue, Chen Zhang, Zhengren Xu, Charlotte Simmler, David C Lankin, Jonathan Bisson, Guido F Pauli
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural product reports 36 (1) (2018)
Liao-Bin Dong, Jeffrey D Rudolf, Ming-Rong Deng, Xiaohui Yan, Ben Shen
Discovery of the Tiancilactone Antibiotics by Genome Mining of Atypical Bacterial Type II Diterpene Synthases. Chembiochem : a European journal of chemical biology (2018)
Xiaohui Yan, Jian-Jun Chen, Ajeeth Adhikari, Christiana N Teijaro, Hui Ming Ge, Ivana Crnovcic, Chin-Yuan Chang, Thibault Annaval, Dong Yang, Christoph Rader, Ben Shen
Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. Organic letters 20 (18) (2018)
Thibault Annaval, Lu Han, Jeffrey D Rudolf, Guangbo Xie, Dong Yang, Chin-Yuan Chang, Ming Ma, Ivana Crnovcic, Mitchell D Miller, Jayashree Soman, Weijun Xu, George N Phillips, Ben Shen
Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway. ACS chemical biology 13 (9) (2018)
Thomas Kwong, Ming Ma, Guohui Pan, null Hindra, Dong Yang, Chunying Yang, Jeremy R Lohman, Jeffrey D Rudolf, John L Cleveland, Ben Shen
P450-Catalyzed Tailoring Steps in Leinamycin Biosynthesis Featuring Regio- and Stereoselective Hydroxylations and Substrate Promiscuities. Biochemistry 57 (33) (2018)
Liao-Bin Dong, Jeffrey D Rudolf, Dingding Kang, Nan Wang, Cyndi Qixin He, Youchao Deng, Yong Huang, K N Houk, Yanwen Duan, Ben Shen
Biosynthesis of thiocarboxylic acid-containing natural products. Nature communications 9 (1) (2018)
Chin-Yuan Chang, Jeremy R Lohman, Tingting Huang, Karolina Michalska, Lance Bigelow, Jeffrey D Rudolf, Robert Jedrzejczak, Xiaohui Yan, Ming Ma, Gyorgy Babnigg, Andrzej Joachimiak, George N Phillips, Ben Shen
Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027. Biochemistry 57 (23) (2018)
Lin Qiu, Kai Tian, Zhongqing Wen, Youchao Deng, Dingding Kang, Haoyu Liang, Xiangcheng Zhu, Ben Shen, Yanwen Duan, Yong Huang
Biomimetic Stereoselective Sulfa-Michael Addition Leads to Platensimycin and Platencin Sulfur Analogues against Methicillin-Resistant Staphylococcus aureus. Journal of natural products 81 (2) (2018)
Xun Guo, Ivana Crnovcic, Chin-Yuan Chang, Jun Luo, Jeremy R Lohman, Monica Papinski, Andreas Bechthold, Geoffrey P Horsman, Ben Shen
PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates. Biochemistry 57 (6) (2018)
Jeffrey D Rudolf, Liao-Bin Dong, Xiao Zhang, Hans Renata, Ben Shen
Cytochrome P450-Catalyzed Hydroxylation Initiating Ether Formation in Platensimycin Biosynthesis. Journal of the American Chemical Society 140 (39) (2018)
James B McAlpine, Shao-Nong Chen, Andrei G Kutateladze, John B MacMillan, Giovanni Appendino, Andersson Barison, Mehdi A Beniddir, Maique Weber Biavatti, Stefan Bluml, Asmaa Boufridi, Mark S Butler, Robert J Capon, Young Hae Choi, David Coppage, Phillip Crews, Michael T Crimmins, Marie Csete, Pradeep Dewapriya, Joseph M Egan, Mary J Garson, Grégory Genta-Jouve, William H Gerwick, Harald Gross, Mary Kay Harper, Precilia Hermanto, James M Hook, Luke Hunter, Damien Jeannerat, Nai-Yun Ji, Tyler A Johnson, David G I Kingston, Hiroyuki Koshino, Hsiau-Wei Lee, Guy Lewin, Jie Li, Roger G Linington, Miaomiao Liu, Kerry L McPhail, Tadeusz F Molinski, Bradley S Moore, Joo-Won Nam, Ram P Neupane, Matthias Niemitz, Jean-Marc Nuzillard, Nicholas H Oberliels, Fernanda Maria Marins Ocampos, Guohui Pan, Ronald J Quinn, D Sai Reddy, Jean-Hugues Renault, José Rivera-Chávez, Wolfgang Robien, Carla M Saunders, Thomas Jürgen Schmidt, Christoph Seger, Ben Shen, Christoph Steinbeck, Hermann Stuppner, Sonja Sturm, Taglialatela-Scafati Orazio, Dean Joseph Tantillo, Robert Verporte, Bin-Gui Wang, Craig M Williams, Philip G Williams, Julien Wist, Jian-Min Yue, Chen Zhang, Zhengren Xu, Charlotte Simmler, David C Lankin, Jonathan Bisson, Guido F Pauli
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research. Natural product reports 36 (1) (2018)
Jian-Jun Chen, Mostafa E Rateb, Melissa S Love, Zhengren Xu, Dong Yang, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Yanwen Duan, Case W McNamara, Ben Shen
Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity. Journal of natural products 81 (4) (2018)
Nan Wang, Jeffrey D Rudolf, Liao-Bin Dong, Jerzy Osipiuk, Catherine Hatzos-Skintges, Michael Endres, Chin-Yuan Chang, Gyorgy Babnigg, Andrzej Joachimiak, George N Phillips, Ben Shen
Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nature chemical biology 14 (7) (2018)
null Hindra, Dong Yang, Qihui Teng, Liao-Bin Dong, Ivana Crnovčić, Tingting Huang, Huiming Ge, Ben Shen
Genome Mining of Streptomyces mobaraensis DSM40847 as a Bleomycin Producer Providing a Biotechnology Platform To Engineer Designer Bleomycin Analogues. Organic letters 19 (6) (2017)
Xiaohui Yan, Jian-Jun Chen, Ajeeth Adhikari, Dong Yang, Ivana Crnovcic, Nan Wang, Chin-Yuan Chang, Christoph Rader, Ben Shen
Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne. Organic letters 19 (22) (2017)
Guohui Pan, Zhengren Xu, Zhikai Guo, null Hindra, Ming Ma, Dong Yang, Hao Zhou, Yannick Gansemans, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Jinhua Cheng, Filip Van Nieuwerburgh, Joo-Won Suh, Yanwen Duan, Ben Shen
Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proceedings of the National Academy of Sciences of the United States of America 114 (52) (2017)
Bo Zhang, Zhengren Xu, Qihui Teng, Guohui Pan, Ming Ma, Ben Shen
A Long-Range Acting Dehydratase Domain as the Missing Link for C17-Dehydration in Iso-Migrastatin Biosynthesis. Angewandte Chemie (International ed. in English) 56 (25) (2017)
Jeffrey D Rudolf, Liao-Bin Dong, Karina Manoogian, Ben Shen
Biosynthetic Origin of the Ether Ring in Platensimycin. Journal of the American Chemical Society 138 (51) (2016)