HSPA5 Inhibitor Meliorate DSS-Induced Colitis through HSPA1A/CHIP.

Fei GaoHeng FanLinping XueZhexing ShouFeng ZhuTing YuSi ChuChunzhu WeiChang LiuDongbo ZuoDongmei Zuo

Published in: Disease markers (2022)

HA15 can improve the differentiation and function of Treg cells by inhibiting the HSPA1A/CHIP pathway, thereby improving ulcerative colitis. Therefore, inhibiting the expression of HSPA5 may serve as a new approach to treat ulcerative colitis.

Keyphrases

ulcerative colitis
heat shock protein
signaling pathway
induced apoptosis
high throughput
circulating tumor cells
poor prognosis
cell cycle arrest
cell proliferation