A phase I/IIa clinical trial of autologous hematopoietic stem cell transplantation in amyotrophic lateral sclerosis.
Christian LunettaAndrea LizioCorrado CabonaFrancesca GerardiValeria Ada SansoneMassimo CorboCarlo ScialòEmanuele AngelucciFrancesca GualandiPaola MarencoGiovanni GrilloRoberto CairoliClara CesanaRiccardo SaccardiMario Giovanni MelazziniGianluigi MancardiClaudia CaponnettoPublished in: Journal of neurology (2022)
aHSCT was overall well tolerated, but it was not followed by any significant modification in disease progression. Considering the negative results of this small trial, further studies aimed to evaluate the possible efficacy of the aHSCT using a higher-intensity regimen should be carefully and with caution evaluated.