MMP11 expression in intratumoral inflammatory cells in breast cancer.

Noemi EiroSandra CidBerta FernándezMaria FraileAna CerneaRosario SánchezAlejandro AndicoecheaEnrique J DeAndrés GalianaLuis O GonzálezZulima Fernández-MuñizJuan L Fernández-MartínezFrancisco J Vizoso

Published in: Histopathology (2019)

Our results showed that MMP11 expression by stromal cells was significantly associated with prognosis. MMP11 expression by cancer-associated fibroblasts (CAFs) was associated with both shortened RFS and OS, but MMP11 expression by MICs showed a stronger association with both shortened RFS and OS, therefore being the most potent and independent factor to predict RFS and OS.

Keyphrases

poor prognosis
binding protein
cell migration
induced apoptosis
oxidative stress
cell proliferation
cell cycle arrest