Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR.
Daniel Castellano-CastilloPierre-Damien DenechaudLluis FajasIsabel Moreno-IndiasWilfredo Oliva-OliveraFrancisco TinahonesMaría Isabel Queipo-OrtuñoFernando CardonaPublished in: PloS one (2019)
H3K4me3 enrichment in the promoter of LEP, LPL, SREBF2, SCD1, PPARG, IL6, TNF and E2F1 is directly associated with increasing BMI and metabolic deterioration. The H3k4me3 mark could be regulating E3F1 mRNA levels in adipose tissue, while no associations between the promoter enrichment of this mark and mRNA levels existed for the other genes studied.
Keyphrases
- adipose tissue
- dna methylation
- genome wide
- body mass index
- insulin resistance
- transcription factor
- endothelial cells
- gene expression
- high fat diet
- genome wide identification
- bioinformatics analysis
- weight gain
- oxidative stress
- induced pluripotent stem cells
- genome wide analysis
- physical activity
- pluripotent stem cells
- skeletal muscle