Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life.
Joshua A BellCaroline J BullMarc J GunterDavid CarslakeAnubha MahajanGeorge Davey SmithNicholas J TimpsonEmma E VincentPublished in: Diabetes care (2020)
Our results support perturbed HDL lipid metabolism as one of the earliest features of type 2 diabetes liability, alongside higher branched-chain amino acid and inflammatory levels. Several features are apparent in childhood as early as age 8 years, decades before the clinical onset of disease.