Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)-induced mouse model for sepsis.

Philip Plaeke Joris G De Man Annemieke Smet Surbhi Malhotra-Kumar Isabel Pintelon Jean-Pierre Timmermans Sara Nullens Philippe G Jorens Guy Hubens Benedicte Y De Winter

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

Treatment with IAP diminished CLP-induced intestinal barrier disruption, associated with modified expression of several cytokines and claudins. Nevertheless, this effect did not translate into better clinical outcomes in our experimental setup.

Keyphrases

mouse model
high glucose
diabetic rats
poor prognosis
intensive care unit
acute kidney injury
oxidative stress
binding protein
ultrasound guided