Class A CpG oligodeoxynucleotide inhibits IFN-γ-induced signaling and apoptosis in lung cancer.

Shuhei TeranishiNobuaki KobayashSeigo KatakuraChisato KamimakiSousuke KuboYuji ShibataMasaki YamamotoMakoto KudoHongmei PiaoTakeshi Kaneko

Published in: Thoracic cancer (2020)

A-CpG and poly-G ODN may overcome tolerance if the cause of ICI tolerance is high IDO expression. However, IFN-γ also has the effect of suppressing apoptosis of cancer cells, and it is necessary to identify the cause of resistance.

Keyphrases

oxidative stress
cell cycle arrest
endoplasmic reticulum stress
dna methylation
dendritic cells
immune response
cell death
diabetic rats
poor prognosis
high glucose
signaling pathway
pi k akt
gene expression
binding protein
long non coding rna