Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model.
Linda M C KoeneSaskia E van GrondelleMartina Proietti OnoriIlse WallaardNathalie H R M KooijmanAnnabel van OortJadwiga SchreiberYpe ElgersmaPublished in: Annals of clinical and translational neurology (2019)
This novel Tsc1 mouse model is highly suitable to assess the efficacy of antiepileptic and -epileptogenic drugs to treat mTORC1-dependent epilepsy. Additionally, it allows us to study the mechanisms underlying mTORC1-mediated epileptogenesis and SUDEP. We found that early treatment with vigabatrin was not able to prevent epilepsy, but significantly delayed seizure onset.