BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas.
Matthew G FieldJeffim N KuznetsovParker L BussiesLouie Z CaiKaram A AlawaChristina L DecaturStefan KurtenbachJ William HarbourPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
This study, coupled with previous work, suggests that the initial event in the divergence of Class 2 UM from Class 1 UM is loss of one copy of chromosome 3, followed by mutation of BAP1 on the remaining copy of chromosome 3, leading to the methylomic repatterning profile characteristic of Class 2 UMs.