FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.

Published in: Molecular medicine (Cambridge, Mass.) (2022)

High FZD7 expression in pancreatic cancer can accelerates hepatic metastases by promoting EMT and strengthening cell stemness, and FZD7 can work through the canonical Wingless-type (WNT) signaling pathway and participate in TGF-β/SMAD3 signaling pathway also.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
signaling pathway
pi k akt
poor prognosis
induced apoptosis
stem cells
single cell
cell proliferation
cell therapy
binding protein
bone marrow
oxidative stress
endoplasmic reticulum stress
cancer stem cells