Antibody-secreting plasma cells persist for decades in human intestine.
Ole J B LandsverkOmri SnirRaquel Bartolomé CasadoLisa RichterJeff E MoldPedro RéuRune HornelandVemund PaulsenSheraz YaqubEinar Martin AandahlOle M ØyenHildur Sif ThorarensenMehran SalehpourGöran PossnertJonas FrisénLudvig M SollidEspen Sønderaal BækkevoldFrode L JahnsenPublished in: The Journal of experimental medicine (2017)
Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19+ PC subset was dynamically exchanged, whereas of two CD19- PC subsets, CD45+ PCs exhibited little and CD45- PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45- PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19- PC subsets support selection and maintenance of protective PCs for life in human intestine.
Keyphrases
- endothelial cells
- bone marrow
- induced apoptosis
- nk cells
- peripheral blood
- single cell
- induced pluripotent stem cells
- magnetic resonance imaging
- cell cycle arrest
- gene expression
- mesenchymal stem cells
- computed tomography
- magnetic resonance
- pregnant women
- pluripotent stem cells
- cell proliferation
- signaling pathway
- bone mineral density
- oxidative stress
- genome wide
- pi k akt
- preterm birth
- pregnancy outcomes