The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer.
Peter G AlexanderAntonia K RoseweirKathryn A F PennelHester C van WykArfon Gethyn Morgan Tregellis PowellDonald C McMillanPaul G HorganCaroline KellyJennifer HayOwen SansomAndrea HarkinCampbell S D RoxburghJanet GrahamDavid N ChurchIan P M TomlinsonMark SaundersTim J IvesonJoanne EdwardsJames Hugh ParkPublished in: British journal of cancer (2020)
This study validates the GMS as a prognostic tool for patients with stage I-III colorectal cancer, independent of TNM, with the ability to stratify both low- and high-risk disease. Furthermore, GMS 0 could be employed to identify a subset of patients that benefit from FOLFOX over CAPOX.