VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.

Zhangya PuDan G DudaYuanyuan ZhuSiya PeiXiaofang WangYan HuangPanpan YiZebing HuangFang PengXingwang HuXuegong Fan

Published in: Journal of translational medicine (2022)

Collectively, these findings demonstrate that VCP is a potential prognostic biomarker in HCC and exhibits oncogenic roles via PI3K/AKT/mTOR pathway activation. HMGB1 played an essential role in VCP-mediated HCC progression, indicating that VCP and HMGB1 are potential therapeutic targets in human HCC.

Keyphrases

endothelial cells
human health
risk assessment
induced pluripotent stem cells
pluripotent stem cells