Inhibition of inflammation and apoptosis through the cyclic GMP-AMP synthase-stimulator of interferon genes pathway by stress granules after ALKBH5 demethylase activation during diabetic myocardial ischaemia-reperfusion injury.
Wenyuan LiRenwu QinZhen TangChangqing WangHeng XuWei LiYan LengYao WangZhong-Yuan XiaPublished in: Diabetes, obesity & metabolism (2024)
Both ALKBH5 and SGs inhibited myocardial inflammation and apoptosis during diabetic myocardial ischaemia-reperfusion. Mechanistically, ALKBH5 might inhibit the apoptosis of cardiomyocytes by promoting the expression of SGs through the cGAS-STING pathway.
Keyphrases
- oxidative stress
- cell cycle arrest
- endoplasmic reticulum stress
- left ventricular
- cell death
- type diabetes
- acute myocardial infarction
- cerebral ischemia
- poor prognosis
- acute ischemic stroke
- wound healing
- dendritic cells
- pi k akt
- heart failure
- escherichia coli
- pseudomonas aeruginosa
- cell proliferation
- brain injury
- atrial fibrillation
- signaling pathway
- blood brain barrier
- long non coding rna
- stress induced
- high glucose
- heat stress