Reverse swing-M, phase 1 study of repurposing mebendazole in recurrent high-grade glioma.

Vijay M PatilArti BhelekarNandini MenonAtanu BhattacharjeeVijai SimhaRam AbhinavAnuja AbhyankarEpari SridharAbhishek MahajanAmeya D PuranikNilendu PurandareAmit JanuAnkita AhujaRahul KrishnatryTejpal GuptaRakesh Jalali

Published in: Cancer medicine (2020)

The recommended phase 2 dose of mebendazole is 1600 mg TDS with temozolomide and temozolomide-radiation combination while the dose of 800 mg TDS needs to be used with single-agent CCNU.

Keyphrases

high grade
newly diagnosed
low grade
open label
clinical trial
randomized controlled trial
radiation induced
radiation therapy
double blind
study protocol