Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage.
Karina Sánchez-AlegríaClorinda AriasPublished in: Endocrinology, diabetes & metabolism (2022)
Understanding the mechanisms that lead to metabolic alterations in neurons induced by saturated FAs could help to develop several strategies for the prevention and treatment of cognitive impairment associated with insulin resistance, metabolic syndrome, or type II diabetes.
Keyphrases
- insulin resistance
- metabolic syndrome
- type diabetes
- cognitive impairment
- adipose tissue
- high fat diet
- fatty acid
- glycemic control
- skeletal muscle
- polycystic ovary syndrome
- high fat diet induced
- cardiovascular disease
- cerebral ischemia
- uric acid
- spinal cord
- resting state
- white matter
- combination therapy
- cardiovascular risk factors
- multiple sclerosis
- weight loss
- functional connectivity