Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes.

Jared G MainaZhanna BalkhiyarovaArie NouwenIgor PupkoAnna UlrichMathilde BoisselAmélie BonnefondPhillippe Froguel Amna Khamis Inga Prokopenko Marika A Kaakinen

Published in: Diabetes care (2023)

Our results highlight the importance to prevent type 2 diabetes at the onset of depressive symptoms and the need to maintain a healthy weight in the context of its effect on depression and type 2 diabetes comorbidity.

Keyphrases

type diabetes
depressive symptoms
glycemic control
sleep quality
cardiovascular disease
insulin resistance
social support
body mass index
weight loss
emergency department
metabolic syndrome