The first concurrent detection of mitochondrial DNA m.3243A>G mutation, deletion, and depletion in a family with mitochondrial diabetes.
Mouna TabebiWajdi SafiRahma FelhiOlfa Alila FersiLeila Ammar KeskesMohamed AbidMouna MnifFaiza FakhfakhPublished in: Molecular genetics & genomic medicine (2020)
Our study points out, for the first time, a severe phenotypic expression of the m.3243A>G point mutation in association with mtDNA deletion and depletion in MD.
Keyphrases
- mitochondrial dna
- copy number
- poor prognosis
- type diabetes
- cardiovascular disease
- oxidative stress
- molecular dynamics
- glycemic control
- early onset
- squamous cell carcinoma
- dna methylation
- locally advanced
- metabolic syndrome
- long non coding rna
- real time pcr
- insulin resistance
- loop mediated isothermal amplification
- radiation therapy
- adipose tissue
- drug induced