Genomic and Immunophenotypic Landscape of Acquired Resistance to PD-(L)1 Blockade in Non-Small-Cell Lung Cancer.
Biagio RicciutiGiuseppe LambertiSreekar R PuchalaNavin R MahadevanJia-Ren LinJoao M Victor AlessiAlexander ChowdhuryYvonne Y LiXinan WangLiam SpurrFederica PecciAlessandro Di FedericoDeepti VenkatramanAdriana P BarrichelloMalini M GandhiVictor R VazAndy J PangilinanDanielle HaradonElinton LeeHersh V GuptaKathleen L PfaffEmma L WelshMizuki NishinoAndrew D CherniackBruce E JohnsonJason L WeiratherIan D DrygScott J RodigLynette M ShollPeter Karl SorgerSandro SantagataRenato UmetonMark M AwadPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
These findings highlight the genomic and immunophenotypic heterogeneity of ICI resistance in NSCLC, which will need to be considered when developing novel therapeutic strategies aimed at overcoming resistance.