Peter K Sorger (P K Sorger)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 89

Top Venues

Molecular systems biology

bioRxiv : the preprint server for biology

Nature communications

Nature

Harvard Medical School

University of Cambridge (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Harvard Medical School

United States

Otto Krayer Professor of Systems Pharmacology :: Systems Biology

Education History

University of Cambridge

United Kingdom

PHD :: Laboratory of Molecular Biology

Publications

Neal P Smith, Yu Yan, Youdong Pan, Jason B Williams, Kasidet Manakongtreecheep, Shishir Pant, Jingxia Zhao, Tian Tian, Timothy Pan, Claire Stingley, Kevin Wu, Jiang Zhang, Alexander L Kley, Peter K Sorger, Alexandra-Chloé Villani, Thomas S Kupper
Resident memory T cell development is associated with AP-1 transcription factor upregulation across anatomical niches. bioRxiv : the preprint server for biology (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature (2023)
Ajit J Nirmal, Clarence Yapp, Sandro Santagata, Peter K Sorger
Cell Spotter (CSPOT): A machine-learning approach to automated cell spotting and quantification of highly multiplexed tissue images. bioRxiv : the preprint server for biology (2023)
Aakanksha Jain, Benjamin M Gyori, Sara Hakim, Samuel Bunga, Daniel G Taub, Mari Carmen Ruiz-Cantero, Candace Tong-Li, Nicholas Andrews, Peter K Sorger, Clifford J Woolf
Nociceptor neuroimmune interactomes reveal cell type- and injury-specific inflammatory pain pathways. bioRxiv : the preprint server for biology (2023)
Gregory J Baker, Edward Novikov, Ziyuan Zhao, Tuulia Vallius, Janae A Davis, Jia-Ren Lin, Jeremy L Muhlich, Elizabeth A Mittendorf, Sandro Santagata, Jennifer L Guerriero, Peter K Sorger
Quality Control for Single Cell Analysis of High-plex Tissue Profiles using CyLinter. bioRxiv : the preprint server for biology (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology 19 (2) (2023)
Clarence Yapp, Ajit J Nirmal, Felix Yuran Zhou, Zoltan Maliga, Paula Montero Llopis, George F Murphy, Christine G Lian, Gaudenz Danuser, Sandro Santagata, Peter K Sorger, null null
Multiplexed 3D Analysis of Cell Plasticity and Immune Niches in Melanoma. bioRxiv : the preprint server for biology (2023)
John A Bachman, Benjamin M Gyori, Peter K Sorger
Automated assembly of molecular mechanisms at scale from text mining and curated databases. Molecular systems biology (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology 19 (2) (2023)
Changchang Liu, Peter Kutchukian, Nhan D Nguyen, Mohammed AlQuraishi, Peter K Sorger
A Hybrid Structure-Based Machine Learning Approach for Predicting Kinase Inhibition by Small Molecules. Journal of chemical information and modeling (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology 19 (2) (2023)
Shannon Coy, Jong Suk Lee, Sabrina J Chan, Terri Woo, Jacquelyn Jones, Sanda Alexandrescu, Patrick Y Wen, Peter K Sorger, Keith L Ligon, Sandro Santagata
Systematic Characterization of Antibody-Drug Conjugate Targets in Central Nervous System Tumors. Neuro-oncology (2023)
Zoltan Maliga, Daniel Y Kim, Ai-Tram N Bui, Jia-Ren Lin, Anna K Dewan, George F Murphy, Ajit J Nirmal, Christine G Lian, Peter K Sorger, Nicole R LeBoeuf
Immune Profiling of Dermatologic Adverse Events from Checkpoint Blockade using Tissue Cyclic Immunofluorescence. bioRxiv : the preprint server for biology (2023)
Marian Kalocsay, Matthew J Berberich, Robert A Everley, Maulik K Nariya, Mirra Chung, Benjamin L Gaudio, Chiara Victor, Gary A Bradshaw, Robyn J Eisert, Marc Hafner, Peter K Sorger, Caitlin E Mills, Kartik Subramanian
Proteomic profiling across breast cancer cell lines and models. Scientific data 10 (1) (2023)
Shannon Coy, Brian Cheng, Jong Suk Lee, Rumana Rashid, Lindsay Browning, Yilin Xu, Sankha S Chakrabarty, Clarence Yapp, Sabrina J Chan, Juliann B Tefft, Emily Scott, Alexander Spektor, Keith L Ligon, Gregory J Baker, David Pellman, Peter K Sorger, Sandro Santagata
2D and 3D multiplexed subcellular profiling of nuclear instability in human cancer. bioRxiv : the preprint server for biology (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology 19 (2) (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology 19 (2) (2023)
Kelly O Conger, Christopher Chidley, Mete Emir Ozgurses, Huiping Zhao, Yumi Kim, Svetlana E Semina, Philippa Burns, Vipin Rawat, Ryan Sheldon, Issam Ben-Sahra, Jonna Frasor, Peter K Sorger, Gina M DeNicola, Jonathan L Coloff
ASCT2 is the primary serine transporter in cancer cells. bioRxiv : the preprint server for biology (2023)
Emmalyn Lecky, Atreyi Mukherji, Rebecca German, Gabriella Antonellis, Jia-Ren Lin, Michael Yorsz, Kelley E McQueeney, Jeremy Adam Ryan, Kimmie Ng, Ewa Sicinska, Peter K Sorger, Anthony G Letai, Patrick D Bhola
Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells. Science advances 9 (25) (2023)
Guihong Wan, Zoltan Maliga, Boshen Yan, Tuulia Vallius, Yingxiao Shi, Sara Khattab, Crystal Chang, Ajit J Nirmal, Kun-Hsing Yu, David Liu, Christine G Lian, Mia S DeSimone, Peter K Sorger, Yevgeniy R Semenov
SpatialCells: Automated Profiling of Tumor Microenvironments with Spatially Resolved Multiplexed Single-Cell Data. bioRxiv : the preprint server for biology (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature 615 (7950) (2023)
Jia-Ren Lin, Yu-An Chen, Daniel Campton, Jeremy Cooper, Shannon Coy, Clarence Yapp, Juliann B Tefft, Erin McCarty, Keith L Ligon, Scott J Rodig, Steven Reese, Thaddeus George, Sandro Santagata, Peter K Sorger
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers. Nature cancer (2023)
Fabian Fröhlich, Luca Gerosa, Jeremy L Muhlich, Peter K Sorger
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance. Molecular systems biology (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature 615 (7950) (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature 615 (7950) (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter K Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature (2023)
Caitlin E Mills, Kartik Subramanian, Marc Hafner, Mario Niepel, Luca Gerosa, Mirra Chung, Chiara Victor, Benjamin Gaudio, Clarence Yapp, Ajit J Nirmal, Nicholas Clark, Peter K Sorger
Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop. Nature communications 13 (1) (2022)
I-M Launonen, N Lyytikäinen, Julia Casado, E A Anttila, A Szabó, U-M Haltia, Connor A Jacobson, J R Lin, Z Maliga, B E Howitt, K C Strickland, Sandro Santagata, K Elias, Alan D' Andrea, Panagiotis A Konstantinopoulos, Peter K Sorger, Anniina Farkkila
Single-cell tumor-immune microenvironment of BRCA1/2 mutated high-grade serous ovarian cancer. Nature communications 13 (1) (2022)
Guihong Wan, Nga Nguyen, Feng Liu, Mia S DeSimone, Bonnie W Leung, Ahmad Rajeh, Michael R Collier, Min Seok Choi, Munachimso Amadife, Kimberly Tang, Shijia Zhang, Jordan S Phillipps, Ruple Jairath, Nora A Alexander, Yining Hua, Meng Jiao, Wenxin Chen, Diane Ho, Stacey Duey, István Balázs Németh, Gyorgy Marko-Varga, Jeovanis Gil Valdés, David R Liu, Genevieve Marie Boland, Alexander Gusev, Peter K Sorger, Kun-Hsing Yu, Yevgeniy R Semenov
Prediction of early-stage melanoma recurrence using clinical and histopathologic features. NPJ precision oncology 6 (1) (2022)
Adam C Palmer, Benjamin Izar, Haeun Hwangbo, Peter K Sorger
Predictable Clinical Benefits without Evidence of Synergy in Trials of Combination Therapies with Immune-Checkpoint Inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (2) (2022)
Deborah Plana, Geoffrey G Fell, Brian M Alexander, Adam C Palmer, Peter K Sorger
Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effects. Nature communications 13 (1) (2022)
Shannon Coy, Shu Wang, Sylwia A Stopka, Jia-Ren Lin, Clarence Yapp, Cecily C Ritch, Lisa Salhi, Gregory J Baker, Rumana Rashid, Gerard Baquer, Michael Regan, Prasidda Khadka, Kristina A Cole, Jaeho Hwang, Patrick Y Wen, Pratiti Bandopadhayay, Mariarita Santi, Thomas De Raedt, Keith L Ligon, Nathalie Y R Agar, Peter K Sorger, Mehdi Touat, Sandro Santagata
Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma. Nature communications 13 (1) (2022)
Giulia Notarangelo, Jessica Brooke Spinelli, Elizabeth M Perez, Gregory J Baker, Kiran Kurmi, Ilaria Elia, Sylwia A Stopka, Gerard Baquer, Jia-Ren Lin, Alexandra J Golby, Shakchhi Joshi, Heide F Baron, Jefte M Drijvers, Peter Georgiev, Alison E Ringel, Elma Zaganjor, Samuel K McBrayer, Peter K Sorger, Arlene H Sharpe, Kai W Wucherpfennig, Sandro Santagata, Nathalie Y R Agar, Mario L Suvà, Marcia C Haigis
Oncometabolite d-2HG alters T cell metabolism to impair CD8 + T cell function. Science (New York, N.Y.) 377 (6614) (2022)
Fabian Fröhlich, Peter K Sorger
Fides: Reliable trust-region optimization for parameter estimation of ordinary differential equation models. PLoS computational biology 18 (7) (2022)
Ajit J Nirmal, Zoltan Maliga, Tuulia Vallius, Brian Quattrochi, Alyce A Chen, Connor A Jacobson, Roxanne J Pelletier, Clarence Yapp, Raquel Arias-Camison, Yu-An Chen, Christine G Lian, George F Murphy, Sandro Santagata, Peter K Sorger
The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution. Cancer discovery 12 (6) (2022)
Denis Schapiro, Clarence Yapp, Artem Sokolov, Sheila M Reynolds, Yu-An Chen, Damir Sudar, Yubin Xie, Jeremy L Muhlich, Raquel Arias-Camison, Sarah Arena, Adam J Taylor, Milen Nikolov, Madison Tyler, Jia-Ren Lin, Erik A Burlingame, null null, Young Hwan Chang, Samouil L Farhi, Vesteinn Thorsson, Nithya Venkatamohan, Julia L Drewes, Dana Pe'er, David A Gutman, Markus D Herrmann, Nils Gehlenborg, Peter Bankhead, Joseph T Roland, John M Herndon, Michael Paul Snyder, R Michael Angelo, Garry Nolan, Jason R Swedlow, Nikolaus Schultz, Daniel T Merrick, Sarah A Mazzili, Ethan Cerami, Scott J Rodig, Sandro Santagata, Peter K Sorger
MITI minimum information guidelines for highly multiplexed tissue images. Nature methods 19 (3) (2022)
Sanja Vickovic, Denis Schapiro, Konstantin Carlberg, Britta Lötstedt, Ludvig Larsson, Franziska Hildebrandt, Marina Korotkova, Aase H Hensvold, Anca I Catrina, Peter K Sorger, Vivianne Malmström, Aviv Regev, Patrik L Ståhl
Three-dimensional spatial transcriptomics uncovers cell type localizations in the human rheumatoid arthritis synovium. Communications biology 5 (1) (2022)
Ratul Chowdhury, Nazim Bouatta, Surojit Biswas, Christina Floristean, Anant Kharkar, Koushik Roy, Charlotte Rochereau, Gustaf Ahdritz, Joanna Zhang, George M Church, Peter K Sorger, Mohammed AlQuraishi
Single-sequence protein structure prediction using a language model and deep learning. Nature biotechnology 40 (11) (2022)
Laura M Doherty, Caitlin E Mills, Sarah A Boswell, Xiaoxi Liu, Charles Tapley Hoyt, Benjamin M Gyori, Sara J Buhrlage, Peter K Sorger
Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes. eLife 11 (2022)
Clarence Yapp, Edward Novikov, Won-Dong Jang, Tuulia Vallius, Yu-An Chen, Marcelo Cicconet, Zoltan Maliga, Connor A Jacobson, Donglai Wei, Sandro Santagata, Hanspeter Pfister, Peter K Sorger
UnMICST: Deep learning with real augmentation for robust segmentation of highly multiplexed images of human tissues. Communications biology 5 (1) (2022)
Giorgio Gaglia, Sheheryar K Kabraji, Danae Rammos, Yang Dai, Ana Verma, Shu Wang, Caitlin E Mills, Mirra Chung, Johann S Bergholz, Shannon Coy, Jia-Ren Lin, Rinath Jeselsohn, Otto Metzger, Eric P Winer, Deborah A Dillon, Jean J Zhao, Peter K Sorger, Sandro Santagata
Temporal and spatial topography of cell proliferation in cancer. Nature cell biology 24 (3) (2022)
Thomas S C Ng, Hui-Yu Hu, Stefan Kronister, Chanseo Lee, Ran Li, Luca Gerosa, Sylwia A Stopka, Danielle M Burgenske, Ishaan Khurana, Michael S Regan, Sreeram Vallabhaneni, Niharika Putta, Ella Scott, Dylan Matvey, Anita Giobbie-Hurder, Rainer H Kohler, Jann N Sarkaria, Sareh Parangi, Peter K Sorger, Nathalie Y R Agar, Heather A Jacene, Ryan J Sullivan, Elizabeth Buchbinder, Hannes Mikula, Ralph Weissleder, Miles A Miller
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy. Science advances 8 (17) (2022)
Sean M Gross, Mark A Dane, Rebecca L Smith, Kaylyn L Devlin, Ian C McLean, Daniel S Derrick, Caitlin E Mills, Kartik Subramanian, Alexandra B London, Denis Torre, John Erol Evangelista, Daniel J B Clarke, Zhuorui Xie, Cemal Erdem, Nicholas Lyons, Ted Natoli, Sarah Pessa, Xiaodong Lu, James Mullahoo, Jonathan Li, Miriam Adam, Brook Wassie, Moqing Liu, David F Kilburn, Tiera A Liby, Elmar Bucher, Crystal Sanchez-Aguila, Kenneth Daily, Larsson Omberg, Yunguan Wang, Connor Jacobson, Clarence Yapp, Mirra Chung, Dusica Vidovic, Yiling Lu, Stephan C Schürer, Albert Lee, Ajay Pillai, Aravind Subramanian, Malvina Papanastasiou, Ernest Fraenkel, Heidi S Feiler, Gordon B Mills, Jacob D Jaffe, Avi Ma'ayan, Marc R Birtwistle, Peter K Sorger, James E Korkola, Joe W Gray, Laura M Heiser
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses. Communications biology 5 (1) (2022)
Deborah Plana, Adam C Palmer, Peter K Sorger
Independent Drug Action in Combination Therapy: Implications for Precision Oncology. Cancer discovery 12 (3) (2022)
Denis Schapiro, Artem Sokolov, Clarence Yapp, Yu-An Chen, Jeremy L Muhlich, Joshua Hess, Allison L Creason, Ajit J Nirmal, Gregory J Baker, Maulik K Nariya, Jia-Ren Lin, Zoltan Maliga, Connor A Jacobson, Matthew W Hodgman, Juha Ruokonen, Samouil L Farhi, Domenic Abbondanza, Eliot T McKinley, Daniel Persson, Courtney Betts, Shamilene Sivagnanam, Aviv Regev, Jeremy Goecks, Robert J Coffey, Lisa M Coussens, Sandro Santagata, Peter K Sorger
MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging. Nature methods (2021)
Malia B McAvoy, Ai-Tram N Bui, Christopher Hansen, Deborah Plana, Jordan T Said, Zizi Yu, Helen Yang, Jacob Freake, Christopher Van, David Krikorian, Avilash K Cramer, Leanne Smith, Liwei Jiang, Karen J Lee, Sara J Li, Brandon Beller, Kimberley Huggins, Michael P Short, Sherry H Yu, Arash Mostaghimi, Peter K Sorger, Nicole R LeBoeuf
3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators. BMC biomedical engineering 3 (1) (2021)
Rumana Rashid, Yu-An Chen, John Hoffer, Jeremy L Muhlich, Jia-Ren Lin, Robert Krueger, Hanspeter Pfister, Richard Mitchell, Sandro Santagata, Peter K Sorger
Narrative online guides for the interpretation of digital-pathology images and tissue-atlas data. Nature biomedical engineering (2021)
Mohammed AlQuraishi, Peter K Sorger
Differentiable biology: using deep learning for biophysics-based and data-driven modeling of molecular mechanisms. Nature methods 18 (10) (2021)
Deborah Plana, Enze Tian, Avilash K Cramer, Helen Yang, Mary M Carmack, Michael S Sinha, Florence T Bourgeois, Sherry H Yu, Peter Masse, Jon Boyer, Minjune Kim, Jinhan Mo, Nicole R LeBoeuf, Ju Li, Peter K Sorger
Assessing the filtration efficiency and regulatory status of N95s and nontraditional filtering face-piece respirators available during the COVID-19 pandemic. BMC infectious diseases 21 (1) (2021)
Steve Rodriguez, Clemens B Hug, Petar V Todorov, Nienke Moret, Sarah A Boswell, Kyle Evans, George Zhou, Nathan T Johnson, Bradley T Hyman, Peter K Sorger, Mark W Albers, Artem Sokolov
Machine learning identifies candidates for drug repurposing in Alzheimer's disease. Nature communications 12 (1) (2021)
Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow
Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling. eLife 10 (2021)
Matthew L Hemming, Shannon Coy, Jia-Ren Lin, Jessica L Andersen, Joanna Przybyl, Emanuele Mazzola, Amr H Abdelhamid Ahmed, Matt van de Rijn, Peter K Sorger, Scott A Armstrong, George D Demetri, Sandro Santagata
HAND1 and BARX1 Act as Transcriptional and Anatomic Determinants of Malignancy in Gastrointestinal Stromal Tumor. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (6) (2021)
Livnat Jerby-Arnon, Cyril Neftel, Marni E Shore, Hannah R Weisman, Nathan D Mathewson, Matthew J McBride, Brian Haas, Benjamin Izar, Angela Volorio, Gaylor Boulay, Luisa Cironi, Alyssa R Richman, Liliane C Broye, Joseph M Gurski, Christina C Luo, Ravindra Mylvaganam, Lan Nguyen, Shaolin Mei, Johannes C Melms, Christophe Georgescu, Ofir Cohen, Jorge E Buendia-Buendia, Asa Segerstolpe, Malika Sud, Michael S Cuoco, Danny Labes, Simon Gritsch, Daniel R Zollinger, Nicole Ortogero, Joseph M Beechem, G Petur Nielsen, Ivan Chebib, Tu Nguyen-Ngoc, Michael Montemurro, Gregory M Cote, Edwin Choy, Igor Letovanec, Stephane Cherix, Nikhil Wagle, Peter K Sorger, Alex B Haynes, John T Mullen, Ivan Stamenkovic, Miguel N Rivera, Cigall Kadoch, Kai W Wucherpfennig, Orit Rozenblatt-Rosen, Mario L Suvà, Nicolò Riggi, Aviv Regev
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nature medicine 27 (2) (2021)
David Liu, Jia-Ren Lin, Emily J Robitschek, Gyulnara G Kasumova, Alex Heyde, Alvin Shi, Adam Kraya, Gao Zhang, Tabea Moll, Dennie T Frederick, Yu-An Chen, Shu Wang, Denis Schapiro, Li-Lun Ho, Kevin Bi, Avinash Sahu, Shaolin Mei, Benchun Miao, Tatyana Sharova, Christopher Alvarez-Breckenridge, Jackson H Stocking, Tommy Kim, Riley Fadden, Donald Lawrence, Mai P Hoang, Daniel P Cahill, Mohsen Malehmir, Martin A Nowak, Priscilla Kaliopi Brastianos, Christine G Lian, Eytan Ruppin, Benjamin Izar, Meenhard Herlyn, Eliezer Van Allen, Katherine L Nathanson, Keith T Flaherty, Ryan J Sullivan, Manolis Kellis, Peter K Sorger, Genevieve Marie Boland
Evolution of delayed resistance to immunotherapy in a melanoma responder. Nature medicine 27 (6) (2021)
Anniina Farkkila, Alfredo Rodríguez, Jaana Oikkonen, Doga C Gulhan, Huy Nguyen, Julieta Domínguez, Sandra Ramos, Caitlin E Mills, Fernando Pérez-Villatoro, Jean-Bernard Lazaro, Jia Zhou, Connor S Clairmont, Lisa A Moreau, Peter J Park, Peter K Sorger, Sampsa Hautaniemi, Sara Frías, Alan D' Andrea
Heterogeneity and Clonal Evolution of Acquired PARP Inhibitor Resistance in TP53- and BRCA1-Deficient Cells. Cancer research 81 (10) (2021)
Steven Rodriguez, Asli Sahin, Benjamin R Schrank, Hawra Al Lawati, Isabel Costantino, Eric Benz, Darian Fard, Alefiya D Albers, Luxiang Cao, Alexis C Gomez, Kyle Evans, Elena Ratti, Merit E Cudkowicz, Matthew P Frosch, Michael E Talkowski, Peter K Sorger, Bradley T Hyman, Mark W Albers
Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss. Science translational medicine 13 (601) (2021)
Akshay Kothakonda, Lyla Atta, Deborah Plana, Ferrous Ward, Chris Davis, Avilash K Cramer, Robert Moran, Jacob Freake, Enze Tian, Ofer Mazor, Pavel Gorelik, Christopher Van, Christopher Hansen, Helen Yang, Michael S Sinha, Ju Li, Sherry H Yu, Nicole R LeBoeuf, Peter K Sorger
De novo Powered Air-Purifying Respirator Design and Fabrication for Pandemic Response. medRxiv : the preprint server for health sciences (2021)
Baishan Jiang, Yang Gao, Jianwei Che, Wen Chao Lu, Ines H Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M Riching, Danette L Daniels, Peter K Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S Gray
Discovery and resistance mechanism of a selective CDK12 degrader. Nature chemical biology 17 (6) (2021)
Avilash K Cramer, Deborah Plana, Helen Yang, Mary M Carmack, Enze Tian, Michael S Sinha, David Krikorian, David Turner, Jinhan Mo, Ju Li, Rajiv Gupta, Heather Manning, Florence T Bourgeois, Sherry H Yu, Peter K Sorger, Nicole R LeBoeuf
Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE. Scientific reports 11 (1) (2021)
Marc-Joseph Antonini, Deborah Plana, Shriya S Srinivasan, Lyla Atta, Aditya Achanta, Helen Yang, Avilash K Cramer, Jacob Freake, Michael S Sinha, Sherry H Yu, Nicole R LeBoeuf, Ben Linville-Engler, Peter K Sorger
A Crisis-Responsive Framework for Medical Device Development Applied to the COVID-19 Pandemic. Frontiers in digital health 3 (2021)
J Bryan Iorgulescu, Prafulla C Gokhale, Maria C Speranza, Benjamin K Eschle, Michael J Poitras, Margaret K Wilkens, Kara M Soroko, Chhayheng Chhoeu, Aine Knott, Yan Gao, Mary Jane Lim-Fat, Gregory J Baker, Dennis M Bonal, Quang-Dé Nguyen, Gareth R L Grant, Keith L Ligon, Peter K Sorger, E Antonio Chiocca, Ana C Anderson, Paul T Kirschmeier, Arlene H Sharpe, Gordon J Freeman, David A Reardon
Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (1) (2020)
Nathan J Schauer, Xiaoxi Liu, Robert S Magin, Laura M Doherty, Wai Cheung Chan, Scott B Ficarro, Wanyi Hu, Rebekka M Roberts, Roxana E Iacob, Björn Stolte, Andrew O Giacomelli, Sumner Perera, Kyle McKay, Sarah A Boswell, Ellen L Weisberg, Arghya Ray, Dharminder Chauhan, Sirano Dhe-Paganon, Ken C Anderson, James D Griffin, Jianing Li, William C Hahn, Peter K Sorger, John R Engen, Kimberly Stegmaier, Jarrod A Marto, Sara J Buhrlage
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism. Scientific reports 10 (1) (2020)
Giorgio Gaglia, Rumana Rashid, Clarence Yapp, Gaurav N Joshi, Carmen G Li, Susan L Lindquist, Kristopher A Sarosiek, Luke Whitesell, Peter K Sorger, Sandro Santagata
HSF1 phase transition mediates stress adaptation and cell fate decisions. Nature cell biology 22 (2) (2020)
Anniina Farkkila, Doga C Gulhan, Julia Casado, Connor A Jacobson, Huy Nguyen, Bose Kochupurakkal, Zoltan Maliga, Clarence Yapp, Yu-An Chen, Denis Schapiro, Yinghui Zhou, Julie R Graham, Bruce J Dezube, Pamela N Munster, Sandro Santagata, Elizabeth Garcia, Scott Rodig, Ana Lako, Dipanjan Chowdhury, Geoffrey I Shapiro, Ursula A Matulonis, Peter J Park, Sampsa Hautaniemi, Peter K Sorger, Elizabeth M Swisher, Alan D' Andrea, Panagiotis A Konstantinopoulos
Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nature communications 11 (1) (2020)
Abishek Chandrashekar, Jinyan Liu, Amanda J Martinot, Katherine A McMahan, Noe B Mercado, Lauren Peter, Lisa H Tostanoski, Jingyou Yu, Zoltan Maliga, Michael Nekorchuk, Kathleen Busman-Sahay, Margaret Terry, Linda M Wrijil, Sarah Ducat, David R Martinez, Caroline G Atyeo, Stephanie Fischinger, John S Burke, Matthew D Slein, Laurent Pessaint, Alex Van Ry, Jack Greenhouse, Tammy Taylor, Kelvin Blade, Anthony Cook, Brad Finneyfrock, Renita Brown, Elyse Teow, Jason Velasco, Roland C Zahn, Frank Wegmann, Peter Abbink, Esther A Bondzie, Gabriel Dagotto, Makda S Gebre, Xuan He, Catherine Jacob-Dolan, Nicole E Kordana, Zhenfeng Li, Michelle A Lifton, Shant H Mahrokhian, Lori F Maxfield, Ramya Nityanandam, Joseph P Nkolola, Aaron G Schmidt, Andrew D Miller, Ralph S Baric, Galit Alter, Peter K Sorger, Jacob D Estes, Hanne A Elyard, Mark G Lewis, Dan H Barouch
SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Science (New York, N.Y.) 369 (6505) (2020)
Deborah Plana, Enze Tian, Avilash K Cramer, Helen Yang, Mary M Carmack, Michael S Sinha, Florence T Bourgeois, Sherry H Yu, Peter Masse, Jon Boyer, Minjune Kim, Jinhan Mo, Nicole R LeBoeuf, Ju Li, Peter K Sorger
Assessing the quality of nontraditional N95 filtering face-piece respirators available during the COVID-19 pandemic. medRxiv : the preprint server for health sciences (2020)
Benjamin Izar, Michael Mints, Elizabeth H Stover, Isaac Wakiro, Michael S Cuoco, Idan Alter, Christopher Rodman, Rachel Leeson, Mei-Ju Su, Parin Shah, Marcin P Iwanicki, Sarah R Walker, Abhay Kanodia, Johannes C Melms, Shaolin Mei, Jia-Ren Lin, Caroline B M Porter, Michal Slyper, Julia Waldman, Livnat Jerby-Arnon, Orr Ashenberg, Titus J Brinker, Caitlin E Mills, Meri Rogava, Sébastien Vigneau, Peter K Sorger, Levi A Garraway, Panagiotis A Konstantinopoulos, Joyce F Liu, Ursula Matulonis, Bruce E Johnson, Orit Rozenblatt-Rosen, Asaf Rotem, Aviv Regev
A single-cell landscape of high-grade serous ovarian cancer. Nature medicine 26 (8) (2020)
Avilash K Cramer, Deborah Plana, Helen Yang, Mary M Carmack, Enze Tian, Michael S Sinha, David Krikorian, David Turner, Jinhan Mo, Ju Li, Rajiv Gupta, Heather Manning, Florence T Bourgeois, Sherry H Yu, Peter K Sorger, Nicole R LeBoeuf
Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE: a quality improvement study. medRxiv : the preprint server for health sciences (2020)
Joseph M Cunningham, Grigoriy Koytiger, Peter K Sorger, Mohammed AlQuraishi
Biophysical prediction of protein-peptide interactions and signaling networks using machine learning. Nature methods 17 (2) (2020)
Tanya E Keenan, Tianyu Li, Tuulia Vallius, Jennifer L Guerriero, Nabihah Tayob, Bose Kochupurakkal, Janae A Davis, Ricardo Pastorello, Rie K Tahara, Leilani Anderson, Jake Conway, Meng X He, Erin Shannon, Robert E Godin, Peter K Sorger, Alan D' Andrea, Beth A Overmoyer, Eric P Winer, Elizabeth A Mittendorf, Eliezer M Van Allen, Geoffrey I Shapiro, Sara M Tolaney
Clinical Efficacy and Molecular Response Correlates of the WEE1 Inhibitor Adavosertib Combined with Cisplatin in Patients with Metastatic Triple-Negative Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (4) (2020)
Adam C Palmer, Deborah Plana, Hui Gao, Joshua M Korn, Guizhi Yang, John Green, Xiamei Zhang, Roberto Velazquez, Margaret E McLaughlin, David A Ruddy, Colleen Kowal, Julie Muszynski, Caroline Bullock, Stacy Rivera, Daniel P Rakiec, GiNell Elliott, Paul Fordjour, Ronald Meyer, Alice Loo, Esther Kurth, Jeffrey A Engelman, Hans Bitter, William R Sellers, Juliet A Williams, Peter K Sorger
A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts. Cancer research 80 (19) (2020)
Anniina Farkkila, Doga C Gulhan, Julia Casado, Connor A Jacobson, Huy Nguyen, Bose Kochupurakkal, Zoltan Maliga, Clarence Yapp, Yu-An Chen, Denis Schapiro, Yinghui Zhou, Julie R Graham, Bruce J Dezube, Pamela N Munster, Sandro Santagata, Elizabeth Garcia, Scott Rodig, Ana Lako, Dipanjan Chowdhury, Geoffrey I Shapiro, Ursula A Matulonis, Peter J Park, Sampsa Hautaniemi, Peter K Sorger, Elizabeth M Swisher, Alan D' Andrea, Panagiotis A Konstantinopoulos
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. Nature communications 11 (1) (2020)
Salma Abdel Magid, Won-Dong Jang, Denis Schapiro, Donglai Wei, James Tompkin, Peter K Sorger, Hanspeter Pfister
Channel Embedding for Informative Protein Identification from Highly Multiplexed Images. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 12265 (2020)
Arash Mostaghimi, Marc-Joseph Antonini, Deborah Plana, Philip D Anderson, Brandon Beller, Edward W Boyer, Amber Fannin, Jacob Freake, Richard Oakley, Michael S Sinha, Leanne Smith, Christopher Van, Helen Yang, Peter K Sorger, Nicole R LeBoeuf, Sherry H Yu
Rapid prototyping and clinical testing of a reusable face shield for health care workers responding to the COVID-19 pandemic. medRxiv : the preprint server for health sciences (2020)
Malia B McAvoy, Ai-Tram N Bui, Christopher Hansen, Deborah Plana, Jordan T Said, Zizi Yu, Helen Yang, Jacob Freake, Christopher Van, David Krikorian, Avilash K Cramer, Leanne Smith, Liwei Jiang, Karen J Lee, Sara J Li, Brandon Beller, Michael P Short, Sherry H Yu, Arash Mostaghimi, Peter K Sorger, Nicole R LeBoeuf
3D Printed frames to enable reuse and improve the fit of N95 and KN95 respirators. medRxiv : the preprint server for health sciences (2020)
Eugenia Lyashenko, Mario Niepel, Purushottam D Dixit, Sang Kyun Lim, Peter K Sorger, Dennis Vitkup
Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks. eLife 9 (2020)
Adam C Palmer, Christopher Chidley, Peter K Sorger
A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity. eLife 8 (2019)
Shu Wang, Jia-Ren Lin, Eduardo D Sontag, Peter K Sorger
Inferring reaction network structure from single-cell, multiplex data, using toric systems theory. PLoS computational biology 15 (12) (2019)
Yuyu Song, Kartik Subramanian, Matthew J Berberich, Steven Rodriguez, Isabel J Latorre, Catherine M Luria, Robert A Everley, Mark W Albers, Timothy J Mitchison, Peter K Sorger
A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Scientific data 6 (2019)
Johannes C Melms, Sreeram Vallabhaneni, Caitlin E Mills, Clarence Yapp, Jia-Yun Chen, Eugenio Morelli, Patricia Waszyk, Sushil Kumar, Derrick Deming, Nienke Moret, Steven Rodriguez, Kartik Subramanian, Meri Rogava, Adam N R Cartwright, Adrienne Luoma, Shaolin Mei, Titus Josef Brinker, David M Miller, Alexander Spektor, Dirk Schadendorf, Nicolo Riggi, Kai W Wucherpfennig, Peter K Sorger, Benjamin Izar
Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity. Cancer research 80 (4) (2019)
Ziming Du, Jia-Ren Lin, Rumana Rashid, Zoltan Maliga, Shu Wang, Jon C Aster, Benjamin Izar, Peter K Sorger, Sandro Santagata
Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging. Nature protocols 14 (10) (2019)
Douglas S Jones, Anne P Jenney, Brian A Joughin, Peter K Sorger, Douglas A Lauffenburger
Inflammatory but not mitogenic contexts prime synovial fibroblasts for compensatory signaling responses to p38 inhibition. Science signaling 11 (520) (2018)
John A Bachman, Benjamin M Gyori, Peter K Sorger
FamPlex: a resource for entity recognition and relationship resolution of human protein families and complexes in biomedical text mining. BMC bioinformatics 19 (1) (2018)
Jia-Ren Lin, Benjamin Izar, Shu Wang, Clarence Yapp, Shaolin Mei, Parin M Shah, Sandro Santagata, Peter K Sorger
Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes. eLife 7 (2018)
Mario Niepel, Marc Hafner, Qiaonan Duan, Zichen Wang, Evan O Paull, Mirra Chung, Xiaodong Lu, Joshua M Stuart, Todd R Golub, Aravind Subramanian, Avi Ma'ayan, Peter K Sorger
Common and cell-type specific responses to anti-cancer drugs revealed by high throughput transcript profiling. Nature communications 8 (1) (2017)
Mohammad Fallahi-Sichani, Verena Becker, Benjamin Izar, Gregory J Baker, Jia-Ren Lin, Sarah A Boswell, Parin Shah, Asaf Rotem, Levi A Garraway, Peter K Sorger
Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de-differentiated state. Molecular systems biology 13 (1) (2017)
Benjamin M Gyori, John A Bachman, Kartik Subramanian, Jeremy L Muhlich, Lucian Galescu, Peter K Sorger
From word models to executable models of signaling networks using automated assembly. Molecular systems biology 13 (11) (2017)

Peter K Sorger.css-eqlu8i{font-size:small;padding-left:4px;} (P K Sorger)

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Peter K Sorger (P K Sorger)