Long non-coding RNAs as novel players in β cell function and type 1 diabetes.
Aashiq H MirzaSimranjeet KaurFlemming PociotPublished in: Human genomics (2017)
We accentuate that the lncRNAs within T1D-loci regions in consort with regulatory variants and enhancer clusters orchestrate the chromatin remodeling in β cells and thereby act as cis/trans-regulatory determinants of islet cell transcriptional programs.
Keyphrases
- transcription factor
- long non coding rna
- type diabetes
- induced apoptosis
- poor prognosis
- genome wide identification
- genome wide
- gene expression
- cell cycle arrest
- single cell
- copy number
- public health
- cell therapy
- cardiovascular disease
- dna damage
- dna methylation
- endoplasmic reticulum stress
- insulin resistance
- stem cells
- binding protein
- cell death
- mesenchymal stem cells
- signaling pathway
- cell proliferation
- pi k akt