Analysis of disease characteristics of a large patient cohort with congenital generalized lipodystrophy from the Middle East and North Africa.
Saif Al YaarubiAfaf AlsagheirAzza Al ShidhaniSomaya AlzelayeNadia AlghazirImad BremaHussain AlsaffarMohammed Al DubayeeAwad AlshahraniYasmine AbdelmeguidOmneya M OmarNajya AttiaElham Al AmiriJamal Al JubehAlbandari AlgethamiHaya AlkhayyatAzad HaleemMouza Al YahyaeiInes KhochtaliSaleha BabliAhmed NugudNandu ThalangeSarah AlbalushiNadia HergliAsma DeebMajid AlfadhelPublished in: Orphanet journal of rare diseases (2024)
This analysis suggests that in addition to the early onset of fat loss, family history and high consanguinity enable the identification of young patients with CGL in the MENA region. In patients with CGL who have not received lipodystrophy-specific treatment, severe metabolic disease and organ abnormalities can develop by late childhood and worsen with age.