Surgical or Percutaneous Coronary Revascularisation for Heart Failure: An In Silico Model using Routinely Collected Health Data to Emulate a Clinical Trial.
Suraj PathakFlorence Y LaiJoanne MikszaMark Colquhoun PetrieMarius RomanSarah MurrayJeremy DearlingDivaka PereraGavin J MurphyPublished in: European heart journal (2022)
In people with heart failure, in-silico modelling suggests that CABG is associated with fewer deaths or cardiovascular hospitalizations at 5 years versus complex PCI. A pragmatic clinical trial is needed to test this hypothesis and this trial would be feasible.
Keyphrases
- clinical trial
- heart failure
- study protocol
- phase ii
- coronary artery disease
- phase iii
- molecular docking
- open label
- atrial fibrillation
- coronary artery bypass grafting
- double blind
- public health
- healthcare
- coronary artery
- left ventricular
- randomized controlled trial
- percutaneous coronary intervention
- acute heart failure
- acute coronary syndrome
- cardiac resynchronization therapy
- electronic health record
- minimally invasive
- acute myocardial infarction
- big data
- mental health
- ultrasound guided
- artificial intelligence
- social media
- human health
- climate change
- aortic valve